Does Psilocybin interact with other substances?

Question: Does Psilocybin interact with any medications or other substances?

Answer: Psilocybin interacts with some other medications. These include SSRIs, MAOIs and other antidepressants. Depending on the preparation method, mushrooms can also interact with acids (like lemon juice) and potentiators (like Syrian Rue). Extra research and caution is suggested before combining Psilocybin with any other substance, even alcohol and cannabis.